Bio-Path Holdings (NASDAQ: BPTH) and Pluristem Therapeutics (NASDAQ:PSTI) are both small-cap medical companies, but which is the superior business? We will compare the two companies based on the strength of their profitability, analyst recommendations, institutional ownership, risk, earnings, valuation and dividends.

Earnings & Valuation

This table compares Bio-Path Holdings and Pluristem Therapeutics’ top-line revenue, earnings per share and valuation.

Gross Revenue Price/Sales Ratio EBITDA Earnings Per Share Price/Earnings Ratio
Bio-Path Holdings $13,000.00 2,462.92 -$8.69 million ($0.07) -4.57
Pluristem Therapeutics N/A N/A -$25.40 million ($0.32) -3.84

Bio-Path Holdings has higher revenue and earnings than Pluristem Therapeutics. Bio-Path Holdings is trading at a lower price-to-earnings ratio than Pluristem Therapeutics, indicating that it is currently the more affordable of the two stocks.

Analyst Ratings

This is a summary of current recommendations and price targets for Bio-Path Holdings and Pluristem Therapeutics, as reported by

Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Bio-Path Holdings 0 0 2 0 3.00
Pluristem Therapeutics 0 0 3 0 3.00

Bio-Path Holdings presently has a consensus price target of $3.50, suggesting a potential upside of 993.75%. Pluristem Therapeutics has a consensus price target of $3.83, suggesting a potential upside of 211.65%. Given Bio-Path Holdings’ higher probable upside, analysts clearly believe Bio-Path Holdings is more favorable than Pluristem Therapeutics.

Volatility & Risk

Bio-Path Holdings has a beta of 3.04, suggesting that its stock price is 204% more volatile than the S&P 500. Comparatively, Pluristem Therapeutics has a beta of 0.1, suggesting that its stock price is 90% less volatile than the S&P 500.

Insider and Institutional Ownership

15.2% of Bio-Path Holdings shares are owned by institutional investors. Comparatively, 4.5% of Pluristem Therapeutics shares are owned by institutional investors. 12.5% of Bio-Path Holdings shares are owned by insiders. Comparatively, 7.0% of Pluristem Therapeutics shares are owned by insiders. Strong institutional ownership is an indication that endowments, large money managers and hedge funds believe a company is poised for long-term growth.


This table compares Bio-Path Holdings and Pluristem Therapeutics’ net margins, return on equity and return on assets.

Net Margins Return on Equity Return on Assets
Bio-Path Holdings N/A -56.53% -43.24%
Pluristem Therapeutics N/A -89.81% -72.46%


Bio-Path Holdings beats Pluristem Therapeutics on 9 of the 10 factors compared between the two stocks.

About Bio-Path Holdings

Bio-Path Holdings, Inc. is a clinical and preclinical stage oncology focused antisense drug development company. The Company utilizes a technology that achieves systemic delivery for target specific protein inhibition for any gene product that is over-expressed in disease. Its drug delivery and antisense technology, DNAbilize, is a platform that uses P-ethoxy, a deoxyribonucleic acid backbone modification. Its lead drug candidate, Liposomal Grb2 (BP1001), targets the protein Growth factor receptor-bound protein 2 (Grb2). Its other liposome delivered antisense drug candidate, Liposomal Bcl2 (BP1002), targets the protein B-cell lymphoma 2 (Bcl2). BP1001 is in Phase II clinical trials for acute myeloid leukemia, and for blast phase and accelerated phase chronic myelogenous leukemia. BP1002 is intended to target the lymphoma and certain solid tumor markets. BP1001 is also in preclinical studies for solid tumors, including triple negative breast cancer and inflammatory breast cancer.

About Pluristem Therapeutics

Pluristem Therapeutics Inc. is a developer of placenta-based cell therapy product candidates for the treatment of multiple ischemic, inflammatory and hematologic conditions. The Company’s lead indications are critical limb ischemia (CLI), recovery after surgery for femoral neck fracture and acute radiation syndrome. Its operations are focused on the research, development, clinical trials and manufacturing of cell therapeutics and related technologies. The Company’s products include PLX-PAD and PLX R18. The Company’s PLX cells are adherent stromal cells (ASCs) that are expanded using a three dimensional (3D) process. The system utilizes a synthetic scaffold to create an artificial 3D environment where placental-derived stromal cells can grow. The Company’s PLX products are administered using a standard needle and syringe. The Company’s PLX products are in clinical-stage development for multiple indications, such as cardiovascular, orthopedic, pulmonary and women’s health diseases.

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