Senestech (NASDAQ: SNES) and Prana Biotechnology (NASDAQ:PRAN) are both small-cap medical companies, but which is the superior investment? We will compare the two businesses based on the strength of their earnings, risk, dividends, analyst recommendations, profitability, institutional ownership and valuation.

Institutional and Insider Ownership

15.3% of Senestech shares are held by institutional investors. Comparatively, 1.8% of Prana Biotechnology shares are held by institutional investors. 27.4% of Senestech shares are held by insiders. Comparatively, 38.8% of Prana Biotechnology shares are held by insiders. Strong institutional ownership is an indication that hedge funds, endowments and large money managers believe a stock will outperform the market over the long term.

Earnings and Valuation

This table compares Senestech and Prana Biotechnology’s revenue, earnings per share and valuation.

Gross Revenue Price/Sales Ratio EBITDA Earnings Per Share Price/Earnings Ratio
Senestech $204,999.00 81.09 -$11.99 million N/A N/A
Prana Biotechnology $2.54 million 1.54 -$5.52 million N/A N/A

Prana Biotechnology has higher revenue and earnings than Senestech.


This table compares Senestech and Prana Biotechnology’s net margins, return on equity and return on assets.

Net Margins Return on Equity Return on Assets
Senestech N/A -303.13% -159.67%
Prana Biotechnology N/A N/A N/A

Analyst Recommendations

This is a breakdown of current ratings and target prices for Senestech and Prana Biotechnology, as reported by

Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Senestech 0 0 2 0 3.00
Prana Biotechnology 0 0 0 0 N/A

Senestech presently has a consensus target price of $14.50, indicating a potential upside of 800.62%. Given Senestech’s higher possible upside, research analysts clearly believe Senestech is more favorable than Prana Biotechnology.


Prana Biotechnology beats Senestech on 5 of the 9 factors compared between the two stocks.

About Senestech

SenesTech, Inc. is a United States-based biotechnology platform and research company. The Company is engaged in developing a technology for managing animal populations by fertility control. It offers ContraPest, a fertility control product candidate. ContraPest’s technology and approach targets the reproductive capabilities of both sexes. Using bait stations, ContraPest is dispensed in a palatable liquid formulation that promotes sustained consumption by rodent communities. Its formulation causes both female and male rats to become infertile once they have consumed the dose. The active ingredient in females accelerates the rate at which ovarian follicles (egg structures) are depleted. Once these cells are gone, the animal cannot reproduce. In males, there is a marked reduction in the ability to fertilize eggs and, often complete sterility. ContraPest is designed, formulated and dispensed for handlers and non-target species, such as wildlife and pets in a biodegradable product.

About Prana Biotechnology

Prana Biotechnology Limited is a development-stage medical biotechnology company. The Company is engaged in the research and development of therapeutic drugs designed to treat the underlying cause of degeneration of the brain focusing on Alzheimer’s disease, Huntington disease, Parkinson’s disease and other neurological disorders. The Company’s lead product candidates are PBT2 and PBT434. The Company’s lead drug candidate PBT2 is being developed for the treatment of Alzheimer’s and Huntington’s diseases. The Company also has advanced a drug candidate for Parkinson’s disease and other movement disorders (PBT434) and brain cancer (PBT519), which are in pre-clinical toxicology testing. Its other applications for its therapies include certain cancers, age-related macular degeneration, Motor Neuron disease, Creutzfeldt-Jakob disease (the human variant of Mad Cow disease), and a range of orphan neurodegenerative disorders.

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